… 7) in which one of the phenyl rings is replaced by a 1-naphthyl … potent new calcilytics. Starting
from the general formula 56, … the development of calhex 231, one of the first calcilytics to be …

… Calhex 231 (N1-(4-Chlorobenzoyl)-N2-[1-(1-naphtyl)ethyl]trans-1,2-diaminocyclohexane),
one of the most potent … in the binding of the calcilytics NPS 2143 and Calhex 231 and the …

… of a known calcilytic compound, Calhex-231. Human … ring opening (B) with (R)-1-(1-naphthyl)
ethylamine (C) was a simple … From Fig 1 we have successfully synthesized Calhex 231 …

… Here we report that the calcimimetic Calindol and the calcilytic … :Calindol(R)-2-[1-(1-naphthyl)
ethylaminomethyl]-1H-indole. (… We have shown previously that Calhex 231 and NPS 2143 …

… the diversity of the receptor's ligands, ligand binding sites and … as well as the calcilytics NPS
2143 and Calhex 231.88, 103 … been demonstrated that signaling from pluripotent receptors …

… orally bioavailable small molecule calcilytic compound that … in potency from hydrogen (6b)
to methyl (6c) to ethyl (1). Some … 18d also demonstrated a desired in vivo activity profile by …

… tend to have higher potency. An orthosteric antagonist of the … ligands of the CaR, recent
studies have demonstrated that … On the other hand, calcilytics, such as NPS 2143 and Calhex 231…

… express high levels of calcium-sensing receptor (CaSR). The … We hypothesize that a
radiolabeled ligand to CaSR may … investigated the calcilytic potency of Calhex 231 and newly …

… the calcium sensing receptor CaSR in peptone sensing in … In the presence of Calhex 231
hydrochloride (10 μM) which … In this study, we observed a strong inhibition of the peptone-…

… N1-Benzoyl-N2-[1-(1naphthyl)ethyl]-trans-1, 2-diaminocyclohexanes: Development of 4-chlorophenylcarboxamide
(Calhex 231) as a new calcium…